The study of the injured brain has focused on exploring regional alterations in brain structure (as delineated from anatomical MRI or diffusion weighted imaging data) and brain function (estimated from functional MRI). More recently, however, an increased interest in the brain as a network has led researchers to explore how structural connectivity (SC) relates to functional connectivity (FC), or what can be called the SC-FC relationship. This project applies novel mathematical frameworks (e.g., multilayer network analysis) to examine whether we can use this SC-FC relationship as a sensitive marker of disease progression and response to injury and treatment.